Nature Communications (Dec 2020)
FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses
- Tarunveer S. Ahluwalia,
- Anders U. Eliasen,
- Astrid Sevelsted,
- Casper-Emil T. Pedersen,
- Jakob Stokholm,
- Bo Chawes,
- Jette Bork-Jensen,
- Niels Grarup,
- Oluf Pedersen,
- Torben Hansen,
- Allan Linneberg,
- Amitabh Sharma,
- Scott T. Weiss,
- Michael D. Evans,
- Daniel J. Jackson,
- Andreanne Morin,
- Karen A. Krogfelt,
- Susanne Schjørring,
- Preben B. Mortensen,
- David M. Hougaard,
- Jonas Bybjerg-Grauholm,
- Marie Bækvad-Hansen,
- Ole Mors,
- Merete Nordentoft,
- Anders D. Børglum,
- Thomas Werge,
- Esben Agerbo,
- James E. Gern,
- Robert F. Lemanske,
- Carole Ober,
- Anders G. Pedersen,
- Hans Bisgaard,
- Klaus Bønnelykke
Affiliations
- Tarunveer S. Ahluwalia
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Anders U. Eliasen
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Astrid Sevelsted
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Casper-Emil T. Pedersen
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Jakob Stokholm
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Bo Chawes
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Jette Bork-Jensen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Niels Grarup
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Oluf Pedersen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Torben Hansen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Allan Linneberg
- Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region
- Amitabh Sharma
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Scott T. Weiss
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Michael D. Evans
- Clinical and Translational Science Institute, University of Minnesota
- Daniel J. Jackson
- Department of Pediatrics, University of Wisconsin
- Andreanne Morin
- Department of Human Genetics, University of Chicago
- Karen A. Krogfelt
- Department of Bacteria, Parasites and Fungi, Statens Serum Institut
- Susanne Schjørring
- Department of Bacteria, Parasites and Fungi, Statens Serum Institut
- Preben B. Mortensen
- iPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research
- David M. Hougaard
- iPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research
- Jonas Bybjerg-Grauholm
- iPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research
- Marie Bækvad-Hansen
- iPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research
- Ole Mors
- iPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research
- Merete Nordentoft
- iPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research
- Anders D. Børglum
- iPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research
- Thomas Werge
- iPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research
- Esben Agerbo
- iPSYCH, The Lundbeck Foundation Initiative for Integrated Psychiatric Research
- James E. Gern
- Department of Pediatrics, University of Wisconsin
- Robert F. Lemanske
- Department of Pediatrics, University of Wisconsin
- Carole Ober
- Department of Human Genetics, University of Chicago
- Anders G. Pedersen
- Section for Bioinformatics, Department of Health Technology, Technical University of Denmark
- Hans Bisgaard
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Klaus Bønnelykke
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- DOI
- https://doi.org/10.1038/s41467-020-19814-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Genetic variants discovered through genome-wide association studies for asthma together account for a small portion of the heritability. Here, the authors identify a possible epistatic relationship between coding variants in FUT2 and ABO, especially pronounced in severe and early onset asthma.
