Influence of LINE-Assisted Provision of Information about Human Papillomavirus and Cervical Cancer Prevention on HPV Vaccine Intention: A Randomized Controlled Trial
Yu Ota,
Kyoko Nomura,
Nozomi Fujita,
Tomoya Suzuki,
Makoto Kamatsuka,
Natsuya Sakata,
Kengo Nagashima,
Junko Hirayama,
Naoko Fujita,
Kuniko Shiga,
Noriaki Oyama,
Yukihiro Terada
Affiliations
Yu Ota
School of Medicine, Faculty of Medicine, Akita University, Akita 0108543, Japan
Kyoko Nomura
Department of Environmental Health Science and Public Health, Akita University Graduate School of Medicine, Akita 0108543, Japan
Nozomi Fujita
School of Medicine, Faculty of Medicine, Akita University, Akita 0108543, Japan
Tomoya Suzuki
School of Medicine, Faculty of Medicine, Akita University, Akita 0108543, Japan
Makoto Kamatsuka
School of Medicine, Faculty of Medicine, Akita University, Akita 0108543, Japan
Natsuya Sakata
School of Medicine, Faculty of Medicine, Akita University, Akita 0108543, Japan
Kengo Nagashima
Biostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, 35 Shinanomachi, Tokyo 1608582, Japan
Junko Hirayama
Department of Environmental Health Science and Public Health, Akita University Graduate School of Medicine, Akita 0108543, Japan
Naoko Fujita
Laboratory of Plant Physiology, Department of Biological Production, Faculty of Bioresource Science, Akita Prefectural University, Akita 0100195, Japan
Kuniko Shiga
Japanese Red Cross Akita College of Nursing, Akita 0101493, Japan
Noriaki Oyama
Department of Gynecology, Akita Red Cross Hospital, Akita 0101495, Japan
Yukihiro Terada
Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita 0108543, Japan
We conducted a prospective, randomized two-arm, parallel group, and open label trial to investigate whether the use of LINE would increase HPV vaccine intention among not completely vaccinated university students. In June 2020, we recruited students aged between 18 and 35 years from four universities in Japan. Among the 357 enrollees (female, 53%), 178 and 179 participants were randomized into the LINE and Mail groups, respectively. At baseline, within three years, vaccine intention was observed in 40% vs. 42% of participants, respectively. At the first intervention, which provided similar PDF leaflets about HPV vaccine and cervical cancer prevention, there was no significant difference in vaccine intention between the two groups. However, at the second intervention of LINE-assisted knowledge intervention for 5 days per week for 7 weeks, the LINE group had a higher proportion of vaccine intention than the no intervention group (66% vs. 44%, OR: 2.62, 95% confidence interval (CI): 1.59–4.35) in per-protocol analysis. The significance remained in the intention-to-treat analysis of multiply imputed datasets. Although LINE did not directly increase HPV vaccine intention compared to conventional posts, the LINE-assisted provision of information was effective in improving HPV vaccine intention among Japanese university and college students.
