Diphenyl Ethers from a Marine-Derived <i>Aspergillus sydowii</i>

Ya-Nan Wang; Yan-Hua Mou; Yu Dong; Yan Wu; Bing-Yu Liu; Jian Bai; Dao-Jiang Yan; Le Zhang; Dan-Qing Feng; Yue-Hu Pei; You-Cai Hu

doi:10.3390/md16110451

Marine Drugs (Nov 2018)

Diphenyl Ethers from a Marine-Derived <i>Aspergillus sydowii</i>

Ya-Nan Wang,
Yan-Hua Mou,
Yu Dong,
Yan Wu,
Bing-Yu Liu,
Jian Bai,
Dao-Jiang Yan,
Le Zhang,
Dan-Qing Feng,
Yue-Hu Pei,
You-Cai Hu

Affiliations

Ya-Nan Wang: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Yan-Hua Mou: School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
Yu Dong: School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
Yan Wu: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Bing-Yu Liu: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Jian Bai: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Dao-Jiang Yan: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Le Zhang: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Dan-Qing Feng: State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean & Earth Sciences, Xiamen University, Xiamen 361102, China
Yue-Hu Pei: School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
You-Cai Hu: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

DOI: https://doi.org/10.3390/md16110451
Journal volume & issue: Vol. 16, no. 11
p. 451

Abstract

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Six new diphenyl ethers (1⁻6) along with eleven known analogs were isolated from the ethyl acetate extract of a marine-derived Aspergillus sydowii guided by LC-UV-MS. Their structures were unambiguously characterized by HRESIMS, NMR, as well as chemical derivatization. Compounds 1 and 2 are rare diphenyl ether glycosides containing d-ribose. The absolute configuration of the sugar moieties in compounds 1⁻3 was determined by a LC-MS method. All the compounds were evaluated for their cytotoxicities against eight cancer cell lines, including 4T1, U937, PC3, HL-60, HT-29, A549, NCI-H460, and K562, and compounds 1, 5, 6, and 8⁻11 were found to exhibit selective cytotoxicity against different cancer cell lines.

Published in Marine Drugs

ISSN: 1660-3397 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/marinedrugs

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