Nature Communications (Mar 2022)

Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells

  • Naomi Kawashima,
  • Yuichi Ishikawa,
  • Jeong Hui Kim,
  • Yoko Ushijima,
  • Akimi Akashi,
  • Yohei Yamaguchi,
  • Hikaru Hattori,
  • Marie Nakashima,
  • Seara Ikeno,
  • Rika Kihara,
  • Takahiro Nishiyama,
  • Takanobu Morishita,
  • Koichi Watamoto,
  • Yukiyasu Ozawa,
  • Kunio Kitamura,
  • Hitoshi Kiyoi

DOI
https://doi.org/10.1038/s41467-022-29304-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 11

Abstract

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Clonal dynamics and selection have not been fully understood in patient-derived xenografts (PDX) of acute myeloid leukemia (AML). Here, the authors generate 160 AML-PDX models to track the clonal dynamics of primary and relapsed AML, and find selectively enriched subclones that are associated with resistance to therapy.