Zhongguo quanke yixue (Jul 2022)

Dynamic Changes and Associated Clinical Value of Serum Soluble α-Klotho Protein for Patients with Severe Craniocerebral Injury

  • Bin REN, Leifang YANG, Xinmin DING, Jifang LIANG

DOI
https://doi.org/10.12114/j.issn.1007-9572.2022.0180
Journal volume & issue
Vol. 25, no. 20
pp. 2493 – 2497

Abstract

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Background The serum soluble α-Klotho protein level may be associated with a lower risk and progression of multiple nervous system diseases. However, there are few reports concerning its dynamic changes and prognostic value in patients with craniocerebral injury. Objective To assess the dynamic changes of serum soluble α-Klotho protein level and associated prognostic value in patients with serious craniocerebral injury. Methods Participants were recruited from Shanxi Bethune Hospital from July 2019 to September 2020, including 103 cases of severe craniocerebral injury with surgical treatment and postoperative monitoring from the ICU (case group, including 74 survived and 29 decreased as of the 28th day posterior to admission) , and 50 physical examinees (healthy controls) . Clinical data of case group were collected. ELISA was used to measure the serum soluble α-Klotho protein level for all participants on the 1st, 3rd, 5th, and 7th days posterior to study enrollment. Results The mean levels of serum soluble α-Klotho protein measured at the four time points in case group were all higher than those of control group (P<0.05) . In case group, the 1st measured mean level of serum soluble α-Klotho protein was lower than the 2nd and 3rd measured levels, the 2nd measured level was higher than the 3rd and 4th measured levels, and the 3rd measured level was higher than the 4th measured level (P<0.05) .The 1st and 4th measured level of serum soluble α-Klotho protein in survival subgroup was higher than that in death subgroup (P<0.05) . In estimating the 28-day in-hospital survival, there was no statistical difference (Z=0.265, P=0.791) in the AUC of serum soluble α-Klotho level measured on postoperative days 1 and 7 {0.686〔95%CI (0.587, 0.774) 〕vs 0.710〔95%CI (0.612, 0.796) 〕} . Conclusion Elevated serum soluble α-Klotho protein was found in severe craniocerebral injury patients, which reached the peak on the 3rd day after injury. So dynamic monitoring of serum soluble α-Klotho protein may contribute to the assessment of patient clinical condition and prognosis.

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