Vascular Biology (Sep 2019)

Ghrelin and vascular protection

  • James T Pearson,
  • Mikiyasu Shirai,
  • Vijayakumar Sukumaran,
  • Cheng-Kun Du,
  • Hirotsugu Tsuchimochi,
  • Takashi Sonobe,
  • Mark T Waddingham,
  • Rajesh Katare,
  • Daryl O Schwenke

DOI
https://doi.org/10.1530/VB-19-0024
Journal volume & issue
Vol. 1, no. 1
pp. H97 – H102

Abstract

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Ghrelin is a small peptide with important roles in the regulation of appetite, gut motility, glucose homeostasis as well as cardiovascular protection. This review highlights the role that acyl ghrelin plays in maintaining normal endothelial function by maintaining the balance of vasodilator-vasoconstrictor factors, inhibiting inflammatory cytokine production and immune cell recruitment to sites of vascular injury and by promoting angiogenesis.

Keywords