Ghrelin and vascular protection

James T Pearson; Mikiyasu Shirai; Vijayakumar Sukumaran; Cheng-Kun Du; Hirotsugu Tsuchimochi; Takashi Sonobe; Mark T Waddingham; Rajesh Katare; Daryl O Schwenke

doi:10.1530/VB-19-0024

Vascular Biology (Sep 2019)

Ghrelin and vascular protection

James T Pearson,
Mikiyasu Shirai,
Vijayakumar Sukumaran,
Cheng-Kun Du,
Hirotsugu Tsuchimochi,
Takashi Sonobe,
Mark T Waddingham,
Rajesh Katare,
Daryl O Schwenke

Affiliations

James T Pearson: Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan; Department of Physiology and Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia
Mikiyasu Shirai: Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Vijayakumar Sukumaran: Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Cheng-Kun Du: Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Hirotsugu Tsuchimochi: Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Takashi Sonobe: Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Mark T Waddingham: Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Rajesh Katare: Department of Physiology, HeartOtago, School of Biomedical Sciences University of Otago, Dunedin, New Zealand
Daryl O Schwenke: Department of Physiology, HeartOtago, School of Biomedical Sciences University of Otago, Dunedin, New Zealand

DOI: https://doi.org/10.1530/VB-19-0024
Journal volume & issue: Vol. 1, no. 1
pp. H97 – H102

Abstract

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Ghrelin is a small peptide with important roles in the regulation of appetite, gut motility, glucose homeostasis as well as cardiovascular protection. This review highlights the role that acyl ghrelin plays in maintaining normal endothelial function by maintaining the balance of vasodilator-vasoconstrictor factors, inhibiting inflammatory cytokine production and immune cell recruitment to sites of vascular injury and by promoting angiogenesis.

Published in Vascular Biology

ISSN: 2516-5658 (Online)
Publisher: Bioscientifica
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system; Science: Physiology
Website: https://vb.bioscientifica.com/

About the journal

Abstract

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