Biocompatible Calcium Ion-Doped Magnesium Ferrite Nanoparticles as a New Family of Photothermal Therapeutic Materials for Cancer Treatment
Panchanathan Manivasagan,
Sekar Ashokkumar,
Ala Manohar,
Ara Joe,
Hyo-Won Han,
Sun-Hwa Seo,
Thavasyappan Thambi,
Hai-Sang Duong,
Nagendra Kumar Kaushik,
Ki Hyeon Kim,
Eun Ha Choi,
Eue-Soon Jang
Affiliations
Panchanathan Manivasagan
Department of Applied Chemistry, Kumoh National Institute of Technology, Daehak-ro 61, Gumi 39177, Republic of Korea
Sekar Ashokkumar
Plasma Bioscience Research Centre, Applied Plasma Medicine Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, Republic of Korea
Ala Manohar
Department of Physics, Yeungnam University, Gyeongsan 38541, Republic of Korea
Ara Joe
Department of Applied Chemistry, Kumoh National Institute of Technology, Daehak-ro 61, Gumi 39177, Republic of Korea
Hyo-Won Han
Department of Applied Chemistry, Kumoh National Institute of Technology, Daehak-ro 61, Gumi 39177, Republic of Korea
Sun-Hwa Seo
Department of Applied Chemistry, Kumoh National Institute of Technology, Daehak-ro 61, Gumi 39177, Republic of Korea
Thavasyappan Thambi
School of Chemical Engineering, Theranostic Macromolecules Research Center, Sungkyunkwan University, Suwon 16419, Republic of Korea
Hai-Sang Duong
Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam
Nagendra Kumar Kaushik
Plasma Bioscience Research Centre, Applied Plasma Medicine Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, Republic of Korea
Ki Hyeon Kim
Department of Physics, Yeungnam University, Gyeongsan 38541, Republic of Korea
Eun Ha Choi
Plasma Bioscience Research Centre, Applied Plasma Medicine Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, Republic of Korea
Eue-Soon Jang
Department of Applied Chemistry, Kumoh National Institute of Technology, Daehak-ro 61, Gumi 39177, Republic of Korea
Novel biocompatible and efficient photothermal (PT) therapeutic materials for cancer treatment have recently garnered significant attention, owing to their effective ablation of cancer cells, minimal invasiveness, quick recovery, and minimal damage to healthy cells. In this study, we designed and developed calcium ion-doped magnesium ferrite nanoparticles (Ca2+-doped MgFe2O4 NPs) as novel and effective PT therapeutic materials for cancer treatment, owing to their good biocompatibility, biosafety, high near-infrared (NIR) absorption, easy localization, short treatment period, remote controllability, high efficiency, and high specificity. The studied Ca2+-doped MgFe2O4 NPs exhibited a uniform spherical morphology with particle sizes of 14.24 ± 1.32 nm and a strong PT conversion efficiency (30.12%), making them promising for cancer photothermal therapy (PTT). In vitro experiments showed that Ca2+-doped MgFe2O4 NPs had no significant cytotoxic effects on non-laser-irradiated MDA-MB-231 cells, confirming that Ca2+-doped MgFe2O4 NPs exhibited high biocompatibility. More interestingly, Ca2+-doped MgFe2O4 NPs exhibited superior cytotoxicity to laser-irradiated MDA-MB-231 cells, inducing significant cell death. Our study proposes novel, safe, high-efficiency, and biocompatible PT therapeutics for treating cancers, opening new vistas for the future development of cancer PTT.
