Green Chemistry Letters and Reviews (Jan 2016)

Novel biodegradable protonic ionic liquid for the Fischer indole synthesis reaction

  • William C. Neuhaus,
  • Ian J. Bakanas,
  • Joseph R. Lizza,
  • Charles T. Boon,
  • Gustavo Moura-Letts

DOI
https://doi.org/10.1080/17518253.2016.1149231
Journal volume & issue
Vol. 9, no. 1
pp. 39 – 43

Abstract

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Novel eco-friendly tetramethylguanidinium propanesulfonic acid trifluoromethylacetate ([TMGHPS][TFA]) ionic liquid was developed as catalyst and medium for the Fischer indole synthesis of a wide variety of hydrazines and ketones. The indole products were isolated in high yields and with minimal amounts of organic solvent. This reaction showed that [TMGHPS][TFA] can be regenerated and reused with reproducible yields without eroding the integrity of the ionic liquid.

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