Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway

Seung-Hyun Shin; Ga Young Lee; Mingyu Lee; Jengmin Kang; Hyun-Woo Shin; Yang-Sook Chun; Jong-Wan Park

doi:10.1038/s41467-018-06606-2

Nature Communications (Oct 2018)

Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway

Seung-Hyun Shin,
Ga Young Lee,
Mingyu Lee,
Jengmin Kang,
Hyun-Woo Shin,
Yang-Sook Chun,
Jong-Wan Park

Affiliations

Seung-Hyun Shin: Department of Biomedical Science, BK21-plus Education Program, Seoul National University College of Medicine
Ga Young Lee: Department of Biomedical Science, BK21-plus Education Program, Seoul National University College of Medicine
Mingyu Lee: Department of Biomedical Science, BK21-plus Education Program, Seoul National University College of Medicine
Jengmin Kang: Department of Biomedical Science, BK21-plus Education Program, Seoul National University College of Medicine
Hyun-Woo Shin: Department of Biomedical Science, BK21-plus Education Program, Seoul National University College of Medicine
Yang-Sook Chun: Department of Biomedical Science, BK21-plus Education Program, Seoul National University College of Medicine
Jong-Wan Park: Department of Biomedical Science, BK21-plus Education Program, Seoul National University College of Medicine

DOI: https://doi.org/10.1038/s41467-018-06606-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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More effective strategies are needed to prevent prostate cancer metastasis. Here they report CBP/p300-interacting transactivator with E/D-rich carboxy-terminal domain-2 (CITED2) to interact with nucleolin, p300, and PRMT5 subunits, and reveal a role of CITED2-nucleolin axis in prostate cancer metastasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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