Nature Communications (Sep 2020)

Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

  • Xiaojing Chi,
  • Xiuying Liu,
  • Conghui Wang,
  • Xinhui Zhang,
  • Xiang Li,
  • Jianhua Hou,
  • Lili Ren,
  • Qi Jin,
  • Jianwei Wang,
  • Wei Yang

DOI
https://doi.org/10.1038/s41467-020-18387-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 7

Abstract

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Here, using a humanized phage display library with recombinant SARS- CoV-2 receptor binding domain (RBD) proteins, the authors identify a number of single domain antibodies (sdAbs) that neutralize SARS-CoV-2 in vitro by inhibiting the interaction of the RDB with the host entry receptor ACE2.