Nature Communications (Jun 2021)

A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

  • Mina-A Jhun,
  • Michael Mendelson,
  • Rory Wilson,
  • Rahul Gondalia,
  • Roby Joehanes,
  • Elias Salfati,
  • Xiaoping Zhao,
  • Kim Valeska Emilie Braun,
  • Anh Nguyet Do,
  • Åsa K. Hedman,
  • Tao Zhang,
  • Elena Carnero-Montoro,
  • Jincheng Shen,
  • Traci M. Bartz,
  • Jennifer A. Brody,
  • May E. Montasser,
  • Jeff R. O’Connell,
  • Chen Yao,
  • Rui Xia,
  • Eric Boerwinkle,
  • Megan Grove,
  • Weihua Guan,
  • Pfeiffer Liliane,
  • Paula Singmann,
  • Martina Müller-Nurasyid,
  • Thomas Meitinger,
  • Christian Gieger,
  • Annette Peters,
  • Wei Zhao,
  • Erin B. Ware,
  • Jennifer A. Smith,
  • Klodian Dhana,
  • Joyce van Meurs,
  • Andre Uitterlinden,
  • Mohammad Arfan Ikram,
  • Mohsen Ghanbari,
  • Deugi Zhi,
  • Stefan Gustafsson,
  • Lars Lind,
  • Shengxu Li,
  • Dianjianyi Sun,
  • Tim D. Spector,
  • Yii-der Ida Chen,
  • Coleen Damcott,
  • Alan R. Shuldiner,
  • Devin M. Absher,
  • Steve Horvath,
  • Philip S. Tsao,
  • Sharon Kardia,
  • Bruce M. Psaty,
  • Nona Sotoodehnia,
  • Jordana T. Bell,
  • Erik Ingelsson,
  • Wei Chen,
  • Abbas Dehghan,
  • Donna K. Arnett,
  • Melanie Waldenberger,
  • Lifang Hou,
  • Eric A. Whitsel,
  • Andrea Baccarelli,
  • Daniel Levy,
  • Myriam Fornage,
  • Marguerite R. Irvin,
  • Themistocles L. Assimes

DOI
https://doi.org/10.1038/s41467-021-23899-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Abnormal blood lipid levels are important risk factors for cardiovascular and other various diseases. Here the authors conduct a large-scale multi-ethnic epigenome-wide association study combined with epigenetic (cis-QTL and eQTM) data, and identify CpG-lipid traits associations that are specific to or common across racial/ethnic groups.