The Influence of Biomimetic Deposition Ca-P Coatings on the Release of Simvastatin from TiO2 Nanotube Array

Abstract

In order to improve the capacity of simvastatin and extend the time of the release of the drug, this experiment adopts bionic-deposition to decorate a layer of octacalcium phosphate (OCP) on the face of TiO2 nanotube array,and respectively discusses what are the appropriate parameters of octacalcium phosphate (OCP) can be generated. Experiments show that loading a layer of octacalcium phosphate can extend the time of the release of the drug. In addition, the presence of simvastatin on the TiO2 nanotube array will be a certain influence on the morphology of octacalcium phosphate. However, simvastatin can be dissolved into the bionic fluid by using bionic deposition. Therefore, by step concentration soaking and then using this method to load OCP with simvastatin can effectively improve the amount of simvastatin loaded and extend drug release

Keywords

• TiO2 nanotube arrays
• Biomimetic deposition
• Simvastatin
• Octacalcium phosphate