Aptamer‐based strategies against SARS‐CoV‐2 viruses
Yihao Huang,
Ximing Chen,
Jialu Zhang,
Wenhai Tian,
Siwen Liu,
Rachel Chun‐Yee Tam,
Chaoyong Yang,
Yanling Song
Affiliations
Yihao Huang
The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation The Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian China
Ximing Chen
The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation The Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian China
Jialu Zhang
The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation The Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian China
Wenhai Tian
The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation The Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian China
Siwen Liu
Department of Microbiology Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam, Hong Kong Special Administrative Region China
Rachel Chun‐Yee Tam
Department of Microbiology Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam, Hong Kong Special Administrative Region China
Chaoyong Yang
The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation The Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian China
Yanling Song
The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation The Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian China
Abstract The COVID‐19 pandemic, caused by SARS‐CoV‐2, has seriously threatened human life and security in recent years and has had a serious impact on economic development. A range of strategies, including antibodies, small‐molecule agents and vaccines, have been developed and widely used to combat SARS‐CoV‐2. However, the uncertain development and susceptibility to mutation of SARS‐CoV‐2 pose challenges to these approaches, making it necessary to develop a broader range of strategies to complement and expand the diversity of attacks against SARS‐CoV‐2. As promising tools against SARS‐CoV‐2, aptamers have attracted wide attention due to their unique molecular properties. In this review, we survey SARS‐CoV‐2 aptamers and aptamer‐based detection tools as well as aptamer‐based therapeutics. In addition, we analyze the potential value of aptamers in the investigation of SARS‐CoV‐2 infection mechanism and vaccine design. Finally, we look forward to the future development direction of aptamers against SARS‐CoV‐2 or other viruses.
