Predicting value of leptin and endothelin-1 toward to unfavorable cardiovascular remodelling in patients with arterial hypertension and metabolic syntrome

Abstract

68 patients with essential arterial hypertension II stage and 1 - 2 degree with documented metabolic syndrome according to IDF (2005) criteria and also 30 healthy volunteers were enrolled to the study. Aim of the study was to defi ne prognostic value of leptin and endothelin-1 in patients with essential arterial hypertension combined with metabolic syndrome. Analysis of obtained resuls showed that cut-off values of leptin and endothelin-1 concerning the risk of cardiovascular remodelling at isolated analysis of these hormones content were 10.1 ng/ml and 3.0 fmol/ml respectively. At the same time prognostically signifi cant model based on four factors (2nd type diabetes mellitus, plasma level of both endothelin-1 > 2.5 fmol/ml and leptin > 9.5 ng/ml and also body mass index >25 kg/m2) was optimal for stratifi cation of the patients into high risk group of unfavorable cardiovascular remodeling onset.While used alone for prognostic aim, factor «diabetes mellitus 2nd type» signifi cantly exceeds other predictors of cardiovascular remodeling taking into consideration specifi ty and verisimilitude of positive result, while it has lesser sensitivity and positive prognostic signifi cance than both leptin and endothelin-1.

Keywords

• arterial hypertension
• metabolic syndrome
• leptin
• endothelin-1
• cardiovascular remodelling