Molecules (Nov 2023)

Visible-Light-Mediated Catalyst-Free [2+2] Cycloaddition Reaction for Dihydrocyclobuta[<i>b</i>]naphthalene-3,8-diones Synthesis under Mild Conditions

  • Hong-Bo Tan,
  • Jia-Ying Zhou,
  • Ying-Shan Liu,
  • Tong Lei,
  • Shi-Yu Wang,
  • Shuang-Shuang Hu,
  • Xu Zhang,
  • Zhi-Gang Xu,
  • Dian-Yong Tang,
  • Zhong-Zhu Chen,
  • Bo-Chu Wang

DOI
https://doi.org/10.3390/molecules28227654
Journal volume & issue
Vol. 28, no. 22
p. 7654

Abstract

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A facile and efficient visible-light-mediated method for directly converting 1,4-naphthoquinones into dihydrocyclo-buta[b]naphthalene-3,8-diones (DHCBNDOs) under mild and clean conditions without using any photocatalysts is reported. This approach exhibited favorable compatibility with functional groups and afforded a series of DHCBNDOs with excellent regioselectivity and high yields. Moreover, detailed mechanism studies were carried out both experimentally and theoretically. The readily accessible, low-cost and ecofriendly nature of the developed strategy will endow it with attractive applications in organic and medicinal chemistry.

Keywords