Translation and natural selection of micropeptides from long non-canonical RNAs

Pedro Patraquim; Emile G. Magny; José I. Pueyo; Ana Isabel Platero; Juan Pablo Couso

doi:10.1038/s41467-022-34094-y

Nature Communications (Oct 2022)

Translation and natural selection of micropeptides from long non-canonical RNAs

Pedro Patraquim,
Emile G. Magny,
José I. Pueyo,
Ana Isabel Platero,
Juan Pablo Couso

Affiliations

Pedro Patraquim: Centro Andaluz de Biología del Desarrollo, CSIC-UPO
Emile G. Magny: Centro Andaluz de Biología del Desarrollo, CSIC-UPO
José I. Pueyo: Brighton and Sussex Medical School
Ana Isabel Platero: Centro Andaluz de Biología del Desarrollo, CSIC-UPO
Juan Pablo Couso: Centro Andaluz de Biología del Desarrollo, CSIC-UPO

DOI: https://doi.org/10.1038/s41467-022-34094-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Translation of 100 to 300 micropeptides from small ORFs within lncRNA was detected by Ribosomal Profiling in Drosophila embryos. These translated small ORFs showed natural selection conserving micropeptide sequence and function.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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