Dynamic nucleosome landscape elicits a noncanonical GATA2 pioneer model

Tianbao Li; Qi Liu; Zhong Chen; Kun Fang; Furong Huang; Xueqi Fu; Qianben Wang; Victor X. Jin

doi:10.1038/s41467-022-30960-x

Nature Communications (Jun 2022)

Dynamic nucleosome landscape elicits a noncanonical GATA2 pioneer model

Tianbao Li,
Qi Liu,
Zhong Chen,
Kun Fang,
Furong Huang,
Xueqi Fu,
Qianben Wang,
Victor X. Jin

Affiliations

Tianbao Li: Department of Molecular Medicine, University of Texas Health Science Center at San Antonio
Qi Liu: Department of Molecular Medicine, University of Texas Health Science Center at San Antonio
Zhong Chen: Department of Pathology and Duke Cancer Institute, Duke University School of Medicine
Kun Fang: Department of Molecular Medicine, University of Texas Health Science Center at San Antonio
Furong Huang: Department of Pathology and Duke Cancer Institute, Duke University School of Medicine
Xueqi Fu: Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University
Qianben Wang: Department of Pathology and Duke Cancer Institute, Duke University School of Medicine
Victor X. Jin: Department of Molecular Medicine, University of Texas Health Science Center at San Antonio

DOI: https://doi.org/10.1038/s41467-022-30960-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

Read online

Here the authors provide a multi-omic study of the nucleosome landscape in LNCaP cells and observe nine functional nucleosome states each with characteristic nucleosome footprints. Upon androgen stimulation, they observed changes in these nucleosome states accompanied by changes in binding and function of pioneer factors, including GATA2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal