Опухоли головы и шеи (Apr 2015)

COMBINED CHEMOTHERAPY INCLUDING PROCARBAZINE (NATULAN) IN THE TREATMENT OF ANAPLASTIC OLIGODENDROGLIOMAS

  • D. R. Naskhletashvili,
  • A. Kh. Bekyashev,
  • V. B. Karakhan,
  • V. A. Aleshin,
  • R. G. Fu,
  • D. M. Belov,
  • E. G. Chmutin

DOI
https://doi.org/10.17650/2222-1468-2012-0-1-14-16
Journal volume & issue
Vol. 0, no. 1
pp. 14 – 16

Abstract

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Our investigation has demonstrated the high efficiency of combined chemotherapy (CT) including procarbazine + lomustine or procarbazine + lomustine + vincristine in patients with anaplastic oligodendrogliomas. Postoperative CT has been recently recommended for patients with deletion of chromosomes 1p and 19q, by taking into account the good prognosis of a therapeutic effect, better parameters of time till progression in this patient group, and a risk for cognitive impairments after brain radiotherapy.

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