Nature Communications (Feb 2021)

Chromosomal coordination and differential structure of asynchronous replicating regions

  • Britny Blumenfeld,
  • Hagit Masika,
  • Marganit Farago,
  • Yishai Yehuda,
  • Lamia Halaseh,
  • Oriya Vardi,
  • Rachel Rapoport,
  • Rena Levin-Klein,
  • Howard Cedar,
  • Yehudit Bergman,
  • Itamar Simon

DOI
https://doi.org/10.1038/s41467-021-21348-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Most regions of the mammalian genome replicate both alleles in a synchronous manner, but some loci have been found to replicate asynchronously and the time of replication of each allele is different. Here the authors, by employing clonal mouse cells from a hybrid strain chart replication timing over the entire genome, using polymorphisms to distinguish between the paternal and maternal alleles.