Study of bone markers in hyperthyroidism: Single centre experience from south India

Abstract

Aim: To evaluate bone health markers and vitamin D status in patients with hyperthyroidism comprehensively, and comparison of same with matched controls. Materials and methods: The study has been done on 30 newly diagnosed hyperthyroid patients and matched controls. Cases were selected after careful exclusion of conditions which adversely affect bone health. Statistical comparisons were performed with Student’s t test. Results: The study group has shown normal calcium (20% had hypocalcemia), normal phosphorus, normal PTH values, raised alkaline phosphatase levels & significant rise in both bone formation (Osteocalcin) and resorption (β-cross laps) markers (P<0.05). In addition 95% of our subjects (patients and controls) were vitamin D deficient (mean-17.2 ng/dl). There is no specific increase in vitamin D deficiency in hyperthyroidism patients. Conclusion: Hyperthyroidism is associated with increased rate of bone remodeling & changes in mineral homeostasis, thereby increases risk of fractures. Associated vitamin D deficiency further deteriorates bone quality. So it is suggested therapeutic vitamin D and calcium supplementation in addition to antithyroid medication.

Keywords

• hyperthyroidism
• vitamin D
• osteocalcin
• β-crosslaps