Advances in the study of the role of neutrophil extracellular traps in the pathogenesis of interstitial lung disease in idiopathic inflammatory myopathy
Zhang Cen,
Bai Ling,
Zhu Jiarui,
Zhao Peipei,
Li Feifei,
Zhuo Cui,
Ma Wenlan,
Zhang Sigong
Affiliations
Zhang Cen
The Second Clinical Medical School, Lanzhou University, Lanzhou 730030, Gansu, China
Bai Ling
The Second Clinical Medical School, Lanzhou University, Lanzhou 730030, Gansu, China
Zhu Jiarui
The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, Gansu, China
Zhao Peipei
The Second Clinical Medical School, Lanzhou University, Lanzhou 730030, Gansu, China
Li Feifei
The Second Clinical Medical School, Lanzhou University, Lanzhou 730030, Gansu, China
Zhuo Cui
The Second Clinical Medical School, Lanzhou University, Lanzhou 730030, Gansu, China
Ma Wenlan
Qinghai University Affiliated Hospital, Xining 810000, Qinghai, China
Zhang Sigong
The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, Gansu, China
Neutrophil extracellular traps play an important role in the body's defense against pathogens, but over-activated neutrophil extracellular traps may damage normal tissues and participate in the occurrence and development of idiopathic inflammatory myopathy associated interstitial lung disease. This review summarized the relationship between neutrophil extracellular traps and idiopathic inflammatory myopathy associated interstitial lung disease as well as the possible pathogenesis found so far, and potential therapeutic targets and directions for future research was discussed based on these findings.
