Exosome DNA: An untold story of cancer

Bikramjit Bhattacharya; Rajib Dhar; Sayantanee Mukherjee; Sukhamoy Gorai; Arikketh Devi; Anand Krishnan; Athanasios Alexiou; Marios Papadakis

doi:10.1002/ctd2.218

Clinical and Translational Discovery (Aug 2023)

Exosome DNA: An untold story of cancer

Bikramjit Bhattacharya,
Rajib Dhar,
Sayantanee Mukherjee,
Sukhamoy Gorai,
Arikketh Devi,
Anand Krishnan,
Athanasios Alexiou,
Marios Papadakis

Affiliations

Bikramjit Bhattacharya: Department of Applied Microbiology, School of Biosciences and Technology Vellore Institute of Technology (VIT) VelloreIndia
Rajib Dhar: Department of Genetic Engineering, Cancer and Stem Cell Biology Laboratory SRM Institute of Science and Technology KattankulathurIndia
Sayantanee Mukherjee: Amrita School of Nano Sciences and Molecular Medicine Amrita Institute of Medical Sciences KochiIndia
Sukhamoy Gorai: Department of Neurological Sciences Rush University Medical Center ChicagoIllinoisUSA
Arikketh Devi: Department of Genetic Engineering, Cancer and Stem Cell Biology Laboratory SRM Institute of Science and Technology KattankulathurIndia
Anand Krishnan: Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences University of the Free State BloemfonteinSouth Africa
Athanasios Alexiou: Department of Science and Engineering Novel Global Community Educational Foundation HebershamNew South WalesAustralia
Marios Papadakis: Department of Surgery II University Hospital Witten‐Herdecke WuppertalGermany

DOI: https://doi.org/10.1002/ctd2.218
Journal volume & issue: Vol. 3, no. 4
pp. n/a – n/a

Abstract

Read online

Abstract Exosome is nanosized tiny membrane‐bound vesicles and is a subpopulation of extracellular vesicles (EVs). In general, it participates in intercellular communication and acts as a messenger of several pathological complications. Exosome and cancer interlink is the most exciting domain of current cancer research. The internal molecular cargos (proteins, lipids, metabolites, miRNA, and DNA) of tumor derived exosomes (TEXs) are capable of transforming normal cells into tumor phenotypes. Exosome DNA is the less explored area of EVs research. It is involved in several events in cancer progression such as uncontrol cell growth, reprogramming of immune cells, metastasis, and therapeutic resistance. Exo‐DNA is also involved in epigenetic alteration, which promotes cancer. It has a great impact on cancer theranostics (biomarker and therapeutics) research. Exo‐DNA‐based cancer examination supports more detailed cancer research.

Published in Clinical and Translational Discovery

ISSN: 2768-0622 (Online)
Publisher: Wiley
Country of publisher: Australia
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://onlinelibrary.wiley.com/journal/27680622

About the journal

Abstract

Keywords