Nature Communications (Jun 2021)
A multicentre validation study of the diagnostic value of plasma neurofilament light
- Nicholas J. Ashton,
- Shorena Janelidze,
- Ahmad Al Khleifat,
- Antoine Leuzy,
- Emma L. van der Ende,
- Thomas K. Karikari,
- Andrea L. Benedet,
- Tharick A. Pascoal,
- Alberto Lleó,
- Lucilla Parnetti,
- Daniela Galimberti,
- Laura Bonanni,
- Andrea Pilotto,
- Alessandro Padovani,
- Jan Lycke,
- Lenka Novakova,
- Markus Axelsson,
- Latha Velayudhan,
- Gil D. Rabinovici,
- Bruce Miller,
- Carmine Pariante,
- Naghmeh Nikkheslat,
- Susan M. Resnick,
- Madhav Thambisetty,
- Michael Schöll,
- Gorka Fernández-Eulate,
- Francisco J. Gil-Bea,
- Adolfo López de Munain,
- Ammar Al-Chalabi,
- Pedro Rosa-Neto,
- Andre Strydom,
- Per Svenningsson,
- Erik Stomrud,
- Alexander Santillo,
- Dag Aarsland,
- John C. van Swieten,
- Sebastian Palmqvist,
- Henrik Zetterberg,
- Kaj Blennow,
- Abdul Hye,
- Oskar Hansson
Affiliations
- Nicholas J. Ashton
- Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg
- Shorena Janelidze
- Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University
- Ahmad Al Khleifat
- Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London
- Antoine Leuzy
- Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University
- Emma L. van der Ende
- Department of Neurology and Alzheimer Center, Erasmus University Medical Center
- Thomas K. Karikari
- Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg
- Andrea L. Benedet
- Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging
- Tharick A. Pascoal
- Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging
- Alberto Lleó
- Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau
- Lucilla Parnetti
- Laboratory of Clinical Neurochemistry, Neurology Clinic, University of Perugia
- Daniela Galimberti
- Fondazione IRCCS Ca’ Granda, Ospedale Policlinico
- Laura Bonanni
- Department of Neuroscience, Imaging and Clinical Sciences, University G.d’Annunzio of Chieti-Pescara
- Andrea Pilotto
- Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia
- Alessandro Padovani
- Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia
- Jan Lycke
- Department of Clinical Neuroscience, Institution of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg
- Lenka Novakova
- Department of Clinical Neuroscience, Institution of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg
- Markus Axelsson
- Department of Clinical Neuroscience, Institution of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg
- Latha Velayudhan
- Department of Old Age Psychiatry, Maurice Wohl Clinical Neuroscience Institute, King’s College London
- Gil D. Rabinovici
- Department of Neurology, University of California San Francisco, Memory and Aging Center
- Bruce Miller
- Department of Neurology, University of California San Francisco, Memory and Aging Center
- Carmine Pariante
- Stress, Psychiatry and Immunology Lab & Perinatal Psychiatry, Maurice Wohl Clinical Neuroscience Institute, King’s College London
- Naghmeh Nikkheslat
- Stress, Psychiatry and Immunology Lab & Perinatal Psychiatry, Maurice Wohl Clinical Neuroscience Institute, King’s College London
- Susan M. Resnick
- Brain Aging and Behavior Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health
- Madhav Thambisetty
- Clinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health
- Michael Schöll
- Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg
- Gorka Fernández-Eulate
- Neurosciences Area, Biodonostia Health Research Institute
- Francisco J. Gil-Bea
- Neurosciences Area, Biodonostia Health Research Institute
- Adolfo López de Munain
- Neurosciences Area, Biodonostia Health Research Institute
- Ammar Al-Chalabi
- Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London
- Pedro Rosa-Neto
- Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging
- Andre Strydom
- Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Per Svenningsson
- Department of Old Age Psychiatry, Maurice Wohl Clinical Neuroscience Institute, King’s College London
- Erik Stomrud
- Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University
- Alexander Santillo
- Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University
- Dag Aarsland
- Department of Old Age Psychiatry, Maurice Wohl Clinical Neuroscience Institute, King’s College London
- John C. van Swieten
- Department of Neurology and Alzheimer Center, Erasmus University Medical Center
- Sebastian Palmqvist
- Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University
- Henrik Zetterberg
- Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg
- Kaj Blennow
- Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg
- Abdul Hye
- Department of Old Age Psychiatry, Maurice Wohl Clinical Neuroscience Institute, King’s College London
- Oskar Hansson
- Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University
- DOI
- https://doi.org/10.1038/s41467-021-23620-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Cerebrospinal fluid neurofilament light (NfL) is a biomarker for neurodegeneration that can also be assessed in blood. Here the authors show in a validation study the potential for plasma NfL as a biomarker for several neurodegenerative diseases.
