ASSOCIATION OF HORMONE RECEPTORS WITH RISK FACTORS AMONG BREAST CANCER PATIENTS

Abstract

Objective: To compare the risk factors with estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) status of breast cancer patients. Study Design: Cross sectional comparative study. Place and Duration of Study: This study was carried out in Multidisciplinary Lab-1 of Army Medical College, National University of Medical Sciences, Rawalpindi, in collaboration with Department of Pathology of Army Medical College, NUMS Rawalpindi, from Jan 2019 to Jan 2020. Methodology: A total of 50 individuals including radiologically diagnosed cases of breast cancer with different stages and 10 healthy controls without cancer. Patients with any co-morbidity were excluded. Participant’s sample was collected and subjected to ER, PR and HER2 estimation. Other factors i.e. age, gender, marital status, breast feeding, menopause status, side of the breast affected were all taken into consideration. Results: Patients characteristics showed that the mean age, marital and menopause status were linked with breast cancer. The data showed that hormone receptors i.e., ER (p=0.0001), PR (p=0.0002) and HER2 (p=0.0001) were positive among most of the cancer patients as compared to the healthy subjects without cancer. There were no association found between age and hormone receptors. Marital status, breast feeding, menopause and side of breasts involved also had no association with hormone receptors. Conclusion: No significant association found between risk factors and hormone recpetors status of breast cancer patients in our population.

Keywords

• breast cancer
• estrogen receptor (er)
• risk factors
• human epidermal growth factor receptor 2 (her2)
• progesterone receptor (pr)