Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes

Yifei Zhong; Kyung Lee; Yueyi Deng; Yueming Ma; Yiping Chen; Xueling Li; Chengguo Wei; Shumin Yang; Tianming Wang; Nicholas J. Wong; Alecia N. Muwonge; Evren U. Azeloglu; Weijia Zhang; Bhaskar Das; John Cijiang He; Ruijie Liu

doi:10.1038/s41467-019-12433-w

Nature Communications (Oct 2019)

Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes

Yifei Zhong,
Kyung Lee,
Yueyi Deng,
Yueming Ma,
Yiping Chen,
Xueling Li,
Chengguo Wei,
Shumin Yang,
Tianming Wang,
Nicholas J. Wong,
Alecia N. Muwonge,
Evren U. Azeloglu,
Weijia Zhang,
Bhaskar Das,
John Cijiang He,
Ruijie Liu

Affiliations

Yifei Zhong: Department of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Kyung Lee: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
Yueyi Deng: Department of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Yueming Ma: Department of Pharmacology, Shanghai University of Traditional Chinese Medicine
Yiping Chen: Department of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Xueling Li: Department of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Chengguo Wei: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
Shumin Yang: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
Tianming Wang: Department of Pharmacology, Shanghai University of Traditional Chinese Medicine
Nicholas J. Wong: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
Alecia N. Muwonge: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
Evren U. Azeloglu: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
Weijia Zhang: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
Bhaskar Das: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
John Cijiang He: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
Ruijie Liu: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-019-12433-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

Arctigenin (ATG) is the major active component of a Chinese herbal remedy known to reduce proteinuria in patients with diabetic kidney disease (DKD). Here, Zhong et al. identify PP2A as a pharmacological target of ATG in podocytes, and find that PP2A is responsible for some of the beneficial effects of ATG in mouse models of DKD.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal