The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer

Guozhen Gao; Simone Hausmann; Natasha M. Flores; Ana Morales Benitez; Jianjun Shen; Xiaojie Yang; Maria D. Person; Sitaram Gayatri; Donghang Cheng; Yue Lu; Bin Liu; Pawel K. Mazur; Mark T. Bedford

doi:10.1038/s41467-023-35864-y

Nature Communications (Jan 2023)

The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer

Guozhen Gao,
Simone Hausmann,
Natasha M. Flores,
Ana Morales Benitez,
Jianjun Shen,
Xiaojie Yang,
Maria D. Person,
Sitaram Gayatri,
Donghang Cheng,
Yue Lu,
Bin Liu,
Pawel K. Mazur,
Mark T. Bedford

Affiliations

Guozhen Gao: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Simone Hausmann: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Natasha M. Flores: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Ana Morales Benitez: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Jianjun Shen: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Xiaojie Yang: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Maria D. Person: Center for Biomedical Research Support, The University of Texas at Austin
Sitaram Gayatri: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Donghang Cheng: Department of Pediatrics, The University of Texas MD Anderson Cancer Center
Yue Lu: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Bin Liu: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Pawel K. Mazur: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Mark T. Bedford: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-023-35864-y
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 15

Abstract

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Protein arginine methylation can contribute to tumor progression. Here the authors show that protein arginine methyltransferase, CARM1, methylates transcription factor NFIB to promote the growth of small cell lung cancers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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