Synthesis, Spectroscopic, and Biological Assessments on Some New Rare Earth Metal Adrenaline Adducts
Sulaiman A. Al Yousef,
Asma S. Al-Wasidi,
Ibtisam I. S. AlZahrani,
Hotoun I. Thawibaraka,
Ahmed M. Naglah,
Shaima A. El-Mowafi,
Omar B. Ibrahim,
Moamen S. Refat,
Ahmed Gaber
Affiliations
Sulaiman A. Al Yousef
Department of Clinical Laboratory Sciences, College of Applied Medical Science, University of Hafr Al Batin, P.O. Box 1803, Hafar Al Batin 31991, Saudi Arabia
Asma S. Al-Wasidi
Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia
Ibtisam I. S. AlZahrani
Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia
Hotoun I. Thawibaraka
Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia
Ahmed M. Naglah
Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Shaima A. El-Mowafi
Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, Dokki, Cairo 12622, Egypt
Omar B. Ibrahim
Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Moamen S. Refat
Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Ahmed Gaber
Department of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Adrenaline (Adr) reacts with chlorides of Y3+, Ce3+, Nd3+ and Sm3+ in methanol at 60 °C to yield metal ion adducts of definite composition. These compounds are characterized by elemental analyses, molar conductivity, UV-Vis., 1H–NMR, Raman laser, scanning electron microscopy, energy-dispersive X-ray spectroscopy (EDX), and mid infrared spectral measurement investigations. The adducts are found to have the formulae [Y2(Adr)2(H2O)8]Cl3.8H2O, [Ce(Adr)2(H2O)2]Cl3.10H2O, [Nd(Adr)2(H2O)2]Cl3.6H2O, and [Sm(Adr)2(H2O)2]Cl3.12H2O, respectively. The two phenolic groups of the catechol moiety are linked to central metal ions based on the infrared and Raman laser spectra. The new compounds were tested against five gram-positive and two-gram negative bacteria, in addition to two Aspergillus strains. Metal adducts were shown to have stronger antibacterial and antifungal properties than free adrenaline compounds.
