Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHA

Marek P. Dąbrowski; Wanda  Stankiewicz; Tadeusz  Płusa; Andrzej  Chciałowski; Stanisław  Szmigielski

doi:10.1080/09629350124376

Mediators of Inflammation (Jan 2001)

Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHA

Marek P. Dąbrowski,
Wanda Stankiewicz,
Tadeusz Płusa,
Andrzej Chciałowski,
Stanisław Szmigielski

Affiliations

Marek P. Dąbrowski: Military Institute of Hygiene and Epidemiology, Department of Microwave Safety, Immunology Laboratory, Szaserów 128, Warsaw 00 909, Poland
Wanda Stankiewicz: Military Institute of Hygiene and Epidemiology, Department of Microwave Safety, Immunology Laboratory, Szaserów 128, Warsaw 00 909, Poland
Tadeusz Płusa: Central Clinical Hospital of Military Medical Academy, Clinic of Pneumonology and Allergy, Warsaw, Poland
Andrzej Chciałowski: Central Clinical Hospital of Military Medical Academy, Clinic of Pneumonology and Allergy, Warsaw, Poland
Stanisław Szmigielski: Military Institute of Hygiene and Epidemiology, Department of Microwave Safety, Immunology Laboratory, Szaserów 128, Warsaw 00 909, Poland

DOI: https://doi.org/10.1080/09629350124376
Journal volume & issue: Vol. 10, no. 3
pp. 101 – 107

Abstract

Read online

Background: Human peripheral blood mononuclear cells (PBMC) left in microcultures for 24 h without mitogen do not respond to subsequent stimulation with PHA. They regain reactivity if the native culture medium is absorbed with other party lymphocytes or partially replaced with the medium from a PHA-stimulated culture. The observations suggest that, during the incubation, some inhibitory agent had accumulated in the culture medium.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

About the journal