Revista de Odontologia da UNESP ()

Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in rats

  • Aurélio Rosa da SILVA JUNIOR,
  • Alex SEMENOFF SEGUNDO,
  • Tereza Aparecida Delle Vedove SEMENOFF,
  • Natalino Francisco da SILVA,
  • Cervantes CAPOROSSI

DOI
https://doi.org/10.1590/1807-2577.03718
Journal volume & issue
Vol. 47, no. 2
pp. 119 – 123

Abstract

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Abstract Introduction With glutamine supplementation there is better performance in the body’s defense system. Objective The aim of this study was to analyze the effect of glutamine supplementation on ligand-induced periodontal disease in rats. Material and method 48 selected male Wistar rats were divided into 4 groups (N = 12): control group (CG) including healthy animals receiving daily saline solution via gavage; glutamine group (GG) including healthy animals receiving oral glutamine supplementation by gavage at a dose of 1.5 g / kg / day; periodontitis group (PG) including animals with induced periodontal disease on both upper sides receiving daily saline solution via gavage; experimental group (EG) including animals with induced periodontal disease on both upper sides receiving daily glutamine via gavage at a dose of 1.5 g / kg / day. On the 30th day, all animals were euthanized by excess anesthetic. Result In the various analyses, the EG (116.63 ± 22.50 mm2) compared to the CG (82.32 ± 7.48 mm2) obtained a p0.05. Conclusion Glutamine supplementation associated with induced periodontal disease demonstrated a smaller amount of bone loss compared to the periodontitis group.

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