Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans

Michelle D. Leach; Rhys A. Farrer; Kaeling Tan; Zhengqiang Miao; Louise A. Walker; Christina A. Cuomo; Robert T. Wheeler; Alistair J. P. Brown; Koon Ho Wong; Leah E. Cowen

doi:10.1038/ncomms11704

Nature Communications (May 2016)

Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans

Michelle D. Leach,
Rhys A. Farrer,
Kaeling Tan,
Zhengqiang Miao,
Louise A. Walker,
Christina A. Cuomo,
Robert T. Wheeler,
Alistair J. P. Brown,
Koon Ho Wong,
Leah E. Cowen

Affiliations

Michelle D. Leach: Aberdeen Fungal Group, University of Aberdeen, Institute of Medical Sciences
Rhys A. Farrer: Genome Sequencing and Analysis Program, Broad Institute of MIT and Harvard
Kaeling Tan: Faculty of Health Sciences, University of Macau
Zhengqiang Miao: Faculty of Health Sciences, University of Macau
Louise A. Walker: Department of Molecular and Biomedical Sciences, University of Maine
Christina A. Cuomo: Genome Sequencing and Analysis Program, Broad Institute of MIT and Harvard
Robert T. Wheeler: Department of Molecular and Biomedical Sciences, University of Maine
Alistair J. P. Brown: Aberdeen Fungal Group, University of Aberdeen, Institute of Medical Sciences
Koon Ho Wong: Faculty of Health Sciences, University of Macau
Leah E. Cowen: Department of Molecular Genetics, University of Toronto

DOI: https://doi.org/10.1038/ncomms11704
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

Read online

The transcription factor Hsf1 and the molecular chaperone Hsp90 modulate the heat shock response in the pathogen Candida albicans. Here, Leach et al. reveal a complex interplay between the two factors that regulates the expression of genes involved in the heat shock response and virulence.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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