Different types of programmed cell death in periodontitis

Abstract

Periodontitis is a chronic inflammatory and destructive disease in which plaque acts as an initiator. Recruitment of host immune cells and production of multiple inflammatory mediators leads to periodontal tissue damage. Programmed cell death (PCD) is a self-destructive process that is actively initiated by cells under specific conditions and can be mainly categorized into apoptosis, necroptosis, autophagy, pyroptosis, ferroptosis, cuproptosis, etc. Different types of programmed cell death have their own distinctive roles in periodontitis. In this review, we summarizes the characteristics of different types of PCD and their role in the progression of periodontitis, in order to provide new research ideas on the pathogenic mechanism of periodontitis and more references for the precise treatment of periodontitis.

Keywords

• |periodontitis|programmed cell death|apoptosis|autophagy|pyroptosis