Communications Biology (Feb 2021)
Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1
- Mimin Zhang,
- Peng Lu,
- Tohru Terada,
- Miaomiao Sui,
- Haruka Furuta,
- Kilico Iida,
- Yukie Katayama,
- Yi Lu,
- Ken Okamoto,
- Michio Suzuki,
- Tomiko Asakura,
- Kentaro Shimizu,
- Fumihiko Hakuno,
- Shin-Ichiro Takahashi,
- Norimoto Shimada,
- Jinwei Yang,
- Tsutomu Ishikawa,
- Jin Tatsuzaki,
- Koji Nagata
Affiliations
- Mimin Zhang
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Peng Lu
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Tohru Terada
- Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Miaomiao Sui
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Haruka Furuta
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Kilico Iida
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Yukie Katayama
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Yi Lu
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Ken Okamoto
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Michio Suzuki
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Tomiko Asakura
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Kentaro Shimizu
- Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Fumihiko Hakuno
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Shin-Ichiro Takahashi
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Norimoto Shimada
- Tokiwa Phytochemical Co. Ltd.
- Jinwei Yang
- Tokiwa Phytochemical Co. Ltd.
- Tsutomu Ishikawa
- Tokiwa Phytochemical Co. Ltd.
- Jin Tatsuzaki
- Tokiwa Phytochemical Co. Ltd.
- Koji Nagata
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- DOI
- https://doi.org/10.1038/s42003-021-01705-1
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 14
Abstract
A compound from Thai black ginger, KPMF-8, was previously found to dramatically promote activation of SIRT1 towards a peptide substrate. Zhang et al. now show that KPMF-8 can be taken up by cells through culture media, directly interacts with SIRT1, and promotes its deacetylation activity toward native substrate more effectively than resveratrol.
