Sema7A/PlxnCl signaling triggers activity-dependent olfactory synapse formation

Nobuko Inoue; Hirofumi Nishizumi; Hiromi Naritsuka; Hiroshi Kiyonari; Hitoshi Sakano

doi:10.1038/s41467-018-04239-z

Nature Communications (May 2018)

Sema7A/PlxnCl signaling triggers activity-dependent olfactory synapse formation

Nobuko Inoue,
Hirofumi Nishizumi,
Hiromi Naritsuka,
Hiroshi Kiyonari,
Hitoshi Sakano

Affiliations

Nobuko Inoue: Department of Brain Function, University of Fukui School of Medicine
Hirofumi Nishizumi: Department of Brain Function, University of Fukui School of Medicine
Hiromi Naritsuka: Department of Physiology, Graduate School of Medicine, The University of Tokyo
Hiroshi Kiyonari: RIKEN Institute
Hitoshi Sakano: Department of Brain Function, University of Fukui School of Medicine

DOI: https://doi.org/10.1038/s41467-018-04239-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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The molecular mechanisms underlying synapse formation in the olfactory bulb are not fully understood. Here the authors demonstrate that semaphorin 7A on olfactory sensory neurons, and its receptor plexin C1 expressed on mitral and tufted cells, is required for correct synapse formation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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