Nature Communications (Apr 2021)

COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system

  • Susanne Rysz,
  • Jonathan Al-Saadi,
  • Anna Sjöström,
  • Maria Farm,
  • Francesca Campoccia Jalde,
  • Michael Plattén,
  • Helen Eriksson,
  • Margareta Klein,
  • Roberto Vargas-Paris,
  • Sven Nyrén,
  • Goran Abdula,
  • Russell Ouellette,
  • Tobias Granberg,
  • Malin Jonsson Fagerlund,
  • Johan Lundberg

DOI
https://doi.org/10.1038/s41467-021-22713-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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The SARS-CoV-2 receptor ACE2 is involved in the Renin-Angiotensin-Aldosterone System (RAAS). Over-activation of RAAS in swine results in a disease state similar to that of COVID-19 in human patients, suggesting that COVID-19 pathophysiology may be driven, at least in part, by an imbalance of this hormonal system.