IL-33 enhances Jagged1 mediated NOTCH1 intracellular domain (NICD) deubiquitination and pathological angiogenesis in proliferative retinopathy

Deepti Sharma; Shivantika Bisen; Geetika Kaur; Eric C. Van Buren; Gadiparthi N. Rao; Nikhlesh K. Singh

doi:10.1038/s42003-022-03432-7

Communications Biology (May 2022)

IL-33 enhances Jagged1 mediated NOTCH1 intracellular domain (NICD) deubiquitination and pathological angiogenesis in proliferative retinopathy

Deepti Sharma,
Shivantika Bisen,
Geetika Kaur,
Eric C. Van Buren,
Gadiparthi N. Rao,
Nikhlesh K. Singh

Affiliations

Deepti Sharma: Integrative Biosciences Center, Wayne State University
Shivantika Bisen: Integrative Biosciences Center, Wayne State University
Geetika Kaur: Integrative Biosciences Center, Wayne State University
Eric C. Van Buren: Department of Oncology, Wayne State University School of Medicine
Gadiparthi N. Rao: Department of Physiology, University of Tennessee Health Science Center
Nikhlesh K. Singh: Integrative Biosciences Center, Wayne State University

DOI: https://doi.org/10.1038/s42003-022-03432-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 16

Abstract

Read online

Loss of IL-33 in a murine model of retinopathy reduces pathological retinal neovascularization, which can be specified to the role of IL-33 in endothelial cells. IL-33 induces sprouting angiogenesis, and it requires NFkappaB-mediated Jagged 1 expression and Notch1 activation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal