Nature Communications (Apr 2021)
Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer
- Rueyhung R. Weng,
- Hsuan-Hsuan Lu,
- Chien-Ting Lin,
- Chia-Chi Fan,
- Rong-Shan Lin,
- Tai-Chung Huang,
- Shu-Yung Lin,
- Yi-Jhen Huang,
- Yi-Hsiu Juan,
- Yi-Chieh Wu,
- Zheng-Ci Hung,
- Chi Liu,
- Xuan-Hui Lin,
- Wan-Chen Hsieh,
- Tzu-Yuan Chiu,
- Jung-Chi Liao,
- Yen-Ling Chiu,
- Shih-Yu Chen,
- Chong-Jen Yu,
- Hsing-Chen Tsai
Affiliations
- Rueyhung R. Weng
- Department of Internal Medicine, National Taiwan University Hospital
- Hsuan-Hsuan Lu
- Department of Internal Medicine, National Taiwan University Hospital
- Chien-Ting Lin
- Tai Cheng Stem Cell Therapy Center, National Taiwan University
- Chia-Chi Fan
- Graduate Institute of Toxicology, College of Medicine, National Taiwan University
- Rong-Shan Lin
- Tai Cheng Stem Cell Therapy Center, National Taiwan University
- Tai-Chung Huang
- Department of Internal Medicine, National Taiwan University Hospital
- Shu-Yung Lin
- Department of Internal Medicine, National Taiwan University Hospital
- Yi-Jhen Huang
- Graduate Institute of Toxicology, College of Medicine, National Taiwan University
- Yi-Hsiu Juan
- Department of Internal Medicine, National Taiwan University Hospital
- Yi-Chieh Wu
- Graduate Institute of Toxicology, College of Medicine, National Taiwan University
- Zheng-Ci Hung
- Department of Internal Medicine, National Taiwan University Hospital
- Chi Liu
- Department of Plant Pathology and Microbiology, National Taiwan University
- Xuan-Hui Lin
- Tai Cheng Stem Cell Therapy Center, National Taiwan University
- Wan-Chen Hsieh
- Institute of Biomedical Sciences, Academia Sinica
- Tzu-Yuan Chiu
- Institute of Atomic and Molecular Sciences, Academia Sinica
- Jung-Chi Liao
- Institute of Atomic and Molecular Sciences, Academia Sinica
- Yen-Ling Chiu
- Graduate Program in Biomedical Informatics, Department of Computer Science and Engineering, College of Informatics, Yuan Ze University
- Shih-Yu Chen
- Institute of Biomedical Sciences, Academia Sinica
- Chong-Jen Yu
- Department of Internal Medicine, National Taiwan University Hospital
- Hsing-Chen Tsai
- Department of Internal Medicine, National Taiwan University Hospital
- DOI
- https://doi.org/10.1038/s41467-021-22433-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Gamma delta (γδ) T cells have potential for use in immunotherapy against tumours. Here, the authors demonstrate that treatment of tumours with DNA methyltransferase inhibitors modulates cytoskeleton arrangements, upregulates adhesion molecules and increases tumour killing by γδ T cells.
