Nature Communications (Oct 2016)

C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility

  • Laura Gómez-H,
  • Natalia Felipe-Medina,
  • Manuel Sánchez-Martín,
  • Owen R. Davies,
  • Isabel Ramos,
  • Ignacio García-Tuñón,
  • Dirk G. de Rooij,
  • Ihsan Dereli,
  • Attila Tóth,
  • José Luis Barbero,
  • Ricardo Benavente,
  • Elena Llano,
  • Alberto M. Pendas

DOI
https://doi.org/10.1038/ncomms13298
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 16

Abstract

Read online

The synaptonemal complex is a meiosis-specific proteinaceous structure that supports homologous chromosome pairs during meiosis. Here, the authors show that SIX6OS1 (of previously unknown function) is part of the synaptonemal complex central element and upon deletion in mice, causes defective chromosome synapsis and infertility.