Exploring the genetic correlations of antisocial behaviour and life history traits
Jorim J. Tielbeek,
J.C. Barnes,
Arne Popma,
Tinca J.C. Polderman,
James J. Lee,
John R.B. Perry,
Danielle Posthuma,
Brian B. Boutwell
Affiliations
Jorim J. Tielbeek
Postdoctoral Researcher, Department of Complex Trait Genomics, VU University Amsterdam, the Netherlands
J.C. Barnes
Associate Professor, School of Criminal Justice, University of Cincinnati, USA
Arne Popma
Professor, Institute for Criminal Law and Criminology, Leiden University, the Netherlands
Tinca J.C. Polderman
Assistant Professor, Department of Complex Trait Genomics, VU University Amsterdam, the Netherlands
James J. Lee
Assistant Professor, Department of Psychology, University of Minnesota, USA
John R.B. Perry
Doctor, School of Clinical Medicine, University of Cambridge, UK
Danielle Posthuma
Professor, Department of Complex Trait Genomics, VU University Amsterdam, the Netherlands
Brian B. Boutwell
Associate Professor of Criminology and Criminal Justice, Department of Epidemiology and Department of Family and Community Medicine, Saint Louis University, USA
Prior evolutionary theory provided reason to suspect that measures of development and reproduction would be correlated with antisocial behaviours in human and non-human species. Behavioural genetics has revealed that most quantitative traits are heritable, suggesting that these phenotypic correlations may share genetic aetiologies. We use genome-wide association study data to estimate the genetic correlations between various measures of reproductive development (N = 52 776–318 863) and antisocial behaviour (N = 31 968). Our genetic correlation analyses demonstrate that alleles associated with higher reproductive output (number of children ever born, rg = 0.50, P = 0.0065) were positively correlated with alleles associated with antisocial behaviour, whereas alleles associated with more delayed reproductive onset (age at first birth, rg = −0.64, P = 0.0008) were negatively associated with alleles linked to antisocial behaviour. Ultimately, these findings coalesce with evolutionary theories suggesting that increased antisocial behaviours may partly represent a faster life history approach, which may be significantly calibrated by genes.
