Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance

Jae-Hoon Ko; Eun-Jeong Joo; Jin Yang Baek; Kyungmin Huh; Sun Young Cho; Cheol-In Kang; Doo Ryeon Chung; Yae-Jean Kim; Eun-Suk Kang; Kyong Ran Peck

Journal of Microbiology, Immunology and Infection (Oct 2021)

Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance

Jae-Hoon Ko,
Eun-Jeong Joo,
Jin Yang Baek,
Kyungmin Huh,
Sun Young Cho,
Cheol-In Kang,
Doo Ryeon Chung,
Yae-Jean Kim,
Eun-Suk Kang,
Kyong Ran Peck

Affiliations

Jae-Hoon Ko: Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Eun-Jeong Joo: Division of Infectious Diseases, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Jin Yang Baek: Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Republic of Korea
Kyungmin Huh: Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Sun Young Cho: Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Cheol-In Kang: Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Doo Ryeon Chung: Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Yae-Jean Kim: Division of Infectious Diseases and Immunodeficiency, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea
Eun-Suk Kang: Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Corresponding author. Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06531, Republic of Korea. Fax: +82 2 3410 2719.
Kyong Ran Peck: Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Corresponding author. Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea. Fax: +82 2 3410 0064.

Journal volume & issue: Vol. 54, no. 5
pp. 983 – 986

Abstract

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In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100% when pairs of kits were used. With three-kit combination, both sensitivity (99.1%) and specificity (100%) increased.

Published in Journal of Microbiology, Immunology and Infection

ISSN: 1684-1182 (Print)
Publisher: Elsevier
Country of publisher: Hong Kong
LCC subjects: Science: Microbiology
Website: https://www.sciencedirect.com/journal/journal-of-microbiology-immunology-and-infection

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Abstract

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