Nature Communications (Sep 2022)
Resolving molecular diffusion and aggregation of antibody proteins with megahertz X-ray free-electron laser pulses
- Mario Reiser,
- Anita Girelli,
- Anastasia Ragulskaya,
- Sudipta Das,
- Sharon Berkowicz,
- Maddalena Bin,
- Marjorie Ladd-Parada,
- Mariia Filianina,
- Hanna-Friederike Poggemann,
- Nafisa Begam,
- Mohammad Sayed Akhundzadeh,
- Sonja Timmermann,
- Lisa Randolph,
- Yuriy Chushkin,
- Tilo Seydel,
- Ulrike Boesenberg,
- Jörg Hallmann,
- Johannes Möller,
- Angel Rodriguez-Fernandez,
- Robert Rosca,
- Robert Schaffer,
- Markus Scholz,
- Roman Shayduk,
- Alexey Zozulya,
- Anders Madsen,
- Frank Schreiber,
- Fajun Zhang,
- Fivos Perakis,
- Christian Gutt
Affiliations
- Mario Reiser
- Department of Physics, AlbaNova University Center, Stockholm University
- Anita Girelli
- Institut für Angewandte Physik, Universität Tübingen
- Anastasia Ragulskaya
- Institut für Angewandte Physik, Universität Tübingen
- Sudipta Das
- Department of Physics, AlbaNova University Center, Stockholm University
- Sharon Berkowicz
- Department of Physics, AlbaNova University Center, Stockholm University
- Maddalena Bin
- Department of Physics, AlbaNova University Center, Stockholm University
- Marjorie Ladd-Parada
- Department of Physics, AlbaNova University Center, Stockholm University
- Mariia Filianina
- Department of Physics, AlbaNova University Center, Stockholm University
- Hanna-Friederike Poggemann
- Department of Physics, AlbaNova University Center, Stockholm University
- Nafisa Begam
- Institut für Angewandte Physik, Universität Tübingen
- Mohammad Sayed Akhundzadeh
- Department Physik, Universität Siegen
- Sonja Timmermann
- Department Physik, Universität Siegen
- Lisa Randolph
- Department Physik, Universität Siegen
- Yuriy Chushkin
- ESRF - The European Synchrotron
- Tilo Seydel
- Institut Laue-Langevin
- Ulrike Boesenberg
- European X-Ray Free-Electron Laser Facility
- Jörg Hallmann
- European X-Ray Free-Electron Laser Facility
- Johannes Möller
- European X-Ray Free-Electron Laser Facility
- Angel Rodriguez-Fernandez
- European X-Ray Free-Electron Laser Facility
- Robert Rosca
- European X-Ray Free-Electron Laser Facility
- Robert Schaffer
- European X-Ray Free-Electron Laser Facility
- Markus Scholz
- European X-Ray Free-Electron Laser Facility
- Roman Shayduk
- European X-Ray Free-Electron Laser Facility
- Alexey Zozulya
- European X-Ray Free-Electron Laser Facility
- Anders Madsen
- European X-Ray Free-Electron Laser Facility
- Frank Schreiber
- Institut für Angewandte Physik, Universität Tübingen
- Fajun Zhang
- Institut für Angewandte Physik, Universität Tübingen
- Fivos Perakis
- Department of Physics, AlbaNova University Center, Stockholm University
- Christian Gutt
- Department Physik, Universität Siegen
- DOI
- https://doi.org/10.1038/s41467-022-33154-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
The European X-ray FreeElectron Laser Facility generates ultrashort hard X-ray pulses with megahertz repetition rate. Here, the authors probe the dynamics of dense antibody protein (Ig-PEG) solutions using megahertz X-ray photon correlation spectroscopy at the European XFEL.
