Clinical, Cosmetic and Investigational Dermatology (Aug 2023)
Pustular Psoriasis in a Patient Treated with Dupilumab for Atopic Dermatitis: A Case Report
Abstract
Li Liu,* Jie Chen,* Kangheng Tang, Feng Li, Si Li, Xiaojie Ding Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaojie Ding, Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, 1st Maoyuan South Road, Shunqing District, Nanchong, Sichuan Province, 637000, People’s Republic of China, Tel +8615881788808, Fax +8681715881788808, Email [email protected]: Psoriasis and atopic dermatitis are relatively common in clinical practice, but it is rare for the two diseases to co-occur in the same patient. Dupilumab, an anti-IL-4/IL-13 monoclonal antibody, has been approved for treating moderate to severe AD. In addition to its therapeutic effects, dupilumab may induce new cutaneous adverse reactions. We report a rare case of pustular psoriasis induced during the treatment of atopic dermatitis with dupilumab. This case demonstrates the need for caution while treating patients with moderate to severe atopic dermatitis and staying vigilant for the emergence of new symptoms, especially with biological agents.Keywords: psoriasis, atopic dermatitis, dupilumab, case report
