Synthesis and cytotoxic evaluation of hydroxycinnamic acid rhodamine B conjugates

Abstract

Four different hydroxycinnamic acid rhodamine B conjugates have been prepared and screened for their cytotoxic activity. In the sulforhodamine B (SRB) assay the majority of the conjugates displayed good cytotoxicity in the low μM range for different human tumor cell lines. Low EC50 values were obtained especially for an apoptose-triggering cinnamic acid rhodamine conjugate 3 holding a piperazinyl spacer and a cinnamoyl moiety.

Keywords

• Hydroxycinnamic acid
• Amides
• Rhodamine B
• Cytotoxicity