Nature Communications (Oct 2020)

Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression

  • Patricia P. Yee,
  • Yiju Wei,
  • Soo-Yeon Kim,
  • Tong Lu,
  • Stephen Y. Chih,
  • Cynthia Lawson,
  • Miaolu Tang,
  • Zhijun Liu,
  • Benjamin Anderson,
  • Krishnamoorthy Thamburaj,
  • Megan M. Young,
  • Dawit G. Aregawi,
  • Michael J. Glantz,
  • Brad E. Zacharia,
  • Charles S. Specht,
  • Hong-Gang Wang,
  • Wei Li

DOI
https://doi.org/10.1038/s41467-020-19193-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 22

Abstract

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Tumour necrosis is associated with tumour aggressiveness and poor outcomes in patients with glioblastomas, but the underlying mechanisms remain poorly understood. Here, the authors show that in a xenograft mouse model of glioblastoma, tumour-infiltrating neutrophils amplify necrosis by promoting myeloperoxidase-induced tumour cell ferroptosis.