Hepatocellular carcinoma arising within a β-catenin mutated inflammatory hepatic adenoma

Abstract

Hepatic adenomas are benign but carry risk of hemorrhage and malignant transformation, the latter complication being more common in those with β-catenin mutations. We report a case of hepatocellular carcinoma arising in a large inflammatory hepatic adenoma (9.2 cm) with β-catenin mutation. Gross pathology, radiology, and histopathology are shown. This case highlights the risk of malignant transformation that accompanies large tumor size, β-catenin activation, and reinforces the need for surgical intervention in such cases.

Keywords

• Hepatic adenoma
• Hepatocellular carcinoma
• Beta-catenin activation
• Inflammatory hepatic adenoma
• Malignant transformation