Nature Communications (Nov 2021)

Photo-induced copper-catalyzed sequential 1,n-HAT enabling the formation of cyclobutanols

  • Zhusong Cao,
  • Jianye Li,
  • Guozhu Zhang

DOI
https://doi.org/10.1038/s41467-021-26670-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 8

Abstract

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Cyclobutanols are difficult structures to access given their inherent ring strain. Here, the authors present a method to form substituted cyclobutanols from a photocatalytic cascade reaction, proceeding via a 1,5- or 1,6-hydrogen atom transfer and subsequent ring closure.