Nature Communications (Nov 2018)

Epithelial cells release adenosine to promote local TNF production in response to polarity disruption

  • Ingrid Poernbacher,
  • Jean-Paul Vincent

DOI
https://doi.org/10.1038/s41467-018-07114-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Epithelial stress can disrupt polarity and activate TNF and JNK signalling that contributes to inflammation and cell damage. Here, the authors show that disruption of apico-basal polarity leads to adenosine release, activating TNF and JNK and driving an inflammatory response during chronic stress.