Communications Biology (Aug 2021)

LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma

  • Angélina Acier,
  • Magali Godard,
  • Fanny Gassiot,
  • Pascal Finetti,
  • Marion Rubis,
  • Jonathan Nowak,
  • François Bertucci,
  • Juan L. Iovanna,
  • Richard Tomasini,
  • Pascaline Lécorché,
  • Guillaume Jacquot,
  • Michel Khrestchatisky,
  • Jamal Temsamani,
  • Cédric Malicet,
  • Sophie Vasseur,
  • Fabienne Guillaumond

DOI
https://doi.org/10.1038/s42003-021-02508-0
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 13

Abstract

Read online

Acier et al. investigated a peptide cargo system, the Fc(A680)-VH4127, that targets PDAC through the LDLR cell-surface receptor. The Fc(A680)-VH4127 was found to specifically target spontaneous pancreatic tumors in KICmice, as well as metastatic pancreatic tumors in liver.