Mesoporous Silica as a Drug Delivery System for Naproxen: Influence of Surface Functionalization
Lukáš Žid,
Vladimír Zeleňák,
Miroslav Almáši,
Adriana Zeleňáková,
Jaroslava Szücsová,
Jozef Bednarčík,
Monika Šuleková,
Alexander Hudák,
Lucia Váhovská
Affiliations
Lukáš Žid
Department of Inorganic Chemistry Faculty of Science, P.J. Šafárik University, Moyzesova 11, SK-041 54 Košice, Slovakia
Vladimír Zeleňák
Department of Inorganic Chemistry Faculty of Science, P.J. Šafárik University, Moyzesova 11, SK-041 54 Košice, Slovakia
Miroslav Almáši
Department of Inorganic Chemistry Faculty of Science, P.J. Šafárik University, Moyzesova 11, SK-041 54 Košice, Slovakia
Adriana Zeleňáková
Institute of Physics, P. J. Šafárik University, Park Angelinum 9, 04001 Košice, Slovakia
Jaroslava Szücsová
Institute of Physics, P. J. Šafárik University, Park Angelinum 9, 04001 Košice, Slovakia
Jozef Bednarčík
Institute of Physics, P. J. Šafárik University, Park Angelinum 9, 04001 Košice, Slovakia
Monika Šuleková
Department of Chemistry, Biochemistry and Biophysics, Institute of Pharmaceutical Chemistry, The University of Veterinary Medicine and Pharmacy, 04181 Košice, Slovakia
Alexander Hudák
Department of Chemistry, Biochemistry and Biophysics, Institute of Pharmaceutical Chemistry, The University of Veterinary Medicine and Pharmacy, 04181 Košice, Slovakia
Lucia Váhovská
Department of Chemistry, Biochemistry and Biophysics, Institute of Pharmaceutical Chemistry, The University of Veterinary Medicine and Pharmacy, 04181 Košice, Slovakia
In this work we describe the relationship between surface modification of hexagonally ordered mesoporous silica SBA-15 and loading/release characteristics of nonsteroidal anti-inflammatory drug (NSAID) naproxen. Mesoporous silica (MPS) was modified with 3-aminopropyl, phenyl and cyclohexyl groups by grafting method. Naproxen was adsorbed into pores of the prepared MPS from ethanol solution using a solvent evaporation method. The release of the drug was performed in buffer medium at pH 2 and physiological solution at pH 7.4. Parent MPSs as well as naproxen loaded MPSs were characterized using physicochemical techniques such as nitrogen adsorption/desorption, thermogravimetric analysis (TG), Zeta potential analysis, Fourier transform infrared spectroscopy (FT-IR), and elemental analysis. The amount of naproxen released from the MPSs into the medium was determined by high-performance liquid chromatography (HPLC). It was shown that the adsorption and desorption characteristics of naproxen are dependent on the pH of the solution and the surface functionalization of the host.
