PROGNOSIS FOR PREDISPOSAL TO DEVELOPMENT OF VIRAL HEPATITIS C BASED ON G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, AND C-592A IL-10 GENE POLYMORPHISMS

Medicinskaâ Immunologiâ. 2006;8(5-6):715-720 DOI 10.15789/1563-0625-2006-5-6-715-720

 

Journal Homepage

Journal Title: Medicinskaâ Immunologiâ

ISSN: 1563-0625 (Print); 2313-741X (Online)

Publisher: SPb RAACI

Society/Institution: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists

LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Country of publisher: Russian Federation

Language of fulltext: Russian

Full-text formats available: PDF

 

AUTHORS

V. V. Avdoshina (ГУ НИИ клинической и экспериментальной лимфологии СО РАМН, Новосибирск)
V. V. Dortman (ГУ НИИ клинической и экспериментальной лимфологии СО РАМН, Новосибирск)
V. I. Konenkov (ГУ НИИ клинической и экспериментальной лимфологии СО РАМН, Новосибирск)
E. V. Beloborodova (Сибирский государственный медицинский университет, Томск)
N. V. Ryasantseva (Сибирский государственный медицинский университет, Томск)
I. O. Naslednikova (Сибирский государственный медицинский университет, Томск)
V. V. Novitsky (Сибирский государственный медицинский университет, Томск)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 12 weeks

 

Abstract | Full Text

Abstract. The main objective of this work was to identify allelic variants of cytokine genes at the polymorphic positions of G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, and C-592A IL-10, and to assess their contribution to predisposition and resistance of human patients to progression of viral hepatitis C infection. We observed significant increase in frequency of T/G T-330G IL-2 genotype in HCV-infected patients, as compared to healthy individuals. Distribution analysis of C-590T promoter alleles of the IL-4 gene displayed a wide overrepresentation of C/T genotype among HCV-infected patients. Likewise, we have shown the G/A genotype of G-308A TNFA to be highly frequent in the group of HCV-infected patients, whereas this genotype was rare in the sample of healthy persons. When analysing allelic frequencies of cytokine genes at these polymorphic positions, we get an opportunity to predict predisposal for the chronic variant of viral hepatitis C in HCV-infected persons.