Moonlighting functions of phosphoglycerate dehydrogenase in cancer
Chuanlong Wang,
Sanqi An,
Lingyang Zhao,
Shuo Li,
Jia Huang,
Wenkai Ren
Affiliations
Chuanlong Wang
The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China; Guangdong Laboratory of Lingnan Modern Agriculture, State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Sanqi An
Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, School of Public Health, Guangxi Medical University, Nanning 530021, China
Lingyang Zhao
Guangdong Laboratory of Lingnan Modern Agriculture, State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Shuo Li
Guangdong Laboratory of Lingnan Modern Agriculture, State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Jia Huang
Guangdong Laboratory of Lingnan Modern Agriculture, State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
Wenkai Ren
The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China; Guangdong Laboratory of Lingnan Modern Agriculture, State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China; Corresponding author
Summary: Phosphoglycerate dehydrogenase (PHGDH) is traditionally known for catalyzing the conversion of 3-phosphoglycerate (3-PG) to 3-phosphonooxypyruvate (3-PHP), a key step in the de novo synthesis of serine. However, recent studies have uncovered that PHGDH exhibits a wide range of non-canonical functions. In addition to its role in metabolic reactions within the glycolytic pathway, PHGDH also participates in the regulation of gene transcription and translation. These newly identified functions significantly alter our understanding of how PHGDH aberrantly regulates tumor cell fate. In this review, we summarize the mechanisms by which PHGDH promotes cancer progression through these non-canonical pathways, potentially offering new therapeutic avenues for cancer.
